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ROS and Cancers Cancer development in humans is a complex process that includes cellular and molecular changes mediated by various endogenous and exogenous stimuli (Sani et al., 2017

The supernatant (40 l) was added to a 160-l reaction mixture containing 143 mM of Na phosphate buffer (pH 7.5), 6.3 mM of EDTA, 0.22 mM of NADPH, and 20 l of 6 mM of 5,5-dithiobis-2-nitrobenzoic acid

[DOI] [PubMed] [Google Scholar] 417.Yoo HY, Chang MS, Rho HM

The decrease in cell viability was almost completely rescued by either iron chelation via deferoxamine (DFO) or by the lipophilic antioxidant ferrostatin- 1 (Fer1), demonstrating that cell death is both iron and reactive- oxygen species (ROS) dependent