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Artificial mitochondria transfer: current challenges, advances, and future applications

Chronic IFN-I stimulation perturbs lipid metabolism and redox balance in exhausted CD8 + T cells, leading to aberrant lipid accumulation and elevated lipid peroxidation, which exaggerates metabolic and functional exhaustion of T cells (46)

10.1155/2022/4911205 14 FanX

As a central antioxidant, glutathione protects cells from the harmful effects of free radicals and supports essential cellular functions, contributing to better overall health and longevity

Additionally, in patients with folic acid deficiency, the plasma levels of methionine and betaine remain unchanged, and the DMG concentration increases, which suggests that betaine, acting as a methyl-group donor, is able to compensate for folic acid deficiencies and ensure the proper functioning of the one-carbon cycle [202,203]