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Arch Toxicol 90(8):18171840 Calella P, Cerullo G, Di Dio M, Liguori F, Di Onofrio V, Gall F et al (2022) Antioxidant, anti-inflammatory and immunomodulatory effects of spirulina in exercise and sport: a systematic review

Metformin, a commonly used type 2 diabetes medication, has been shown in recent studies to activate AMPK signaling pathways, thereby promoting macrophage fatty acid oxidation and inducing M2 polarization

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They also contain an enzyme called papain that reduces inflammation and improves circulation