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A six-month, multicenter observational study enrolled 197 stroke subjects (mean age, 81.5 years) with a progressive decline of their mental health and general confusion and/or stupor who were initially administered citicoline for 5 or 10 days (2,000 mg/day, by intravenous infusion) within a four-month period, and then for 21 days (1,000 mg/day, by intramuscular injection), repeated once after a seven-day washout period (93)

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Only a couple of studies have evaluated sex differences in changes in CBF following TBI

Most patients need continued therapy to maintain benefits, though some may attempt supervised discontinuation after achieving significant metabolic improvements

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