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Add water slowly to the DMSO solution (with gentle mixing) to avoid local precipitation4

This stress arises from the forced upregulation of glycolysis due to the biguanide-induced reduction in OXPHOS

Major Dopaminergic Pathways in the Brain The substantia nigra within the brain is home to an estimated 135,000 dopaminergic neurons, although counts are species- and method-dependent, 35,000 of which are present in the ventral tegmental area (VTA)