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To effectively address the pathogenic impact of heavy metals, novel therapeutic strategies have been proposed, including multi-target interventions such as antioxidants (12), metal chelators (13), inflammasome inhibitors (14), and epigenetic modifications (15)

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However, the above results were not in agreement with a former research based on a Swedish population, which suggests that SOD genetic polymorphism may confer a race-specific contribution ( Potassium Ion (K + ) Cycling Related Genes As an important charge carrier in the process of sound sensory conduction, K + can be secreted to the endolymph, and then utilized by the sensory hair cells of the inner ear through the mechanically sensitive K + channel, and this ion circulation ensures the generation of hearing