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IFN- further enhances the expression of NKG2D on NK cells, which interacts with UL16-binding protein (ULBP1-6) and MHC class I chain-related proteins A and B (MICA/B) on tumor cells, enhancing the direct cytotoxicity of NK cells [58, 59]

You lose the benefit of the intact "master" molecule

Pellissier et al

and in older individuals, hypothyroidism accelerates cognitive decline while hyperthyroidism increases anxiety and sleep disturbances ( The thyroidbrain axis represents a complex system of bidirectional communication between endocrine and neural networks