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Available from: Hoiting BH et al (1996): Modulation of agonist-induced phosphoinositide metabolism, Ca2+ signalling and contraction of airway smooth muscle by cyclic AMP-dependent mechanisms

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mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding

This is due to more steps being required in manufacturing purified proteins compared to that of small molecule drugs ( Future directions Due to the imperfect therapeutic efficacy and the extremely high costs associated with current treatments, there is a pressing need for novel therapeutics

In addition, mutations at nucleotide 454 were found in 7 of the 17 high-exposure subjects and six of the 24 medium-exposure subjects, but no mutations were found in the three low-exposure patients or in 107 unexposed subjects