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doi: 10.1016/j.nmd.2021.02.020 104

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Figure 2 Fatty Acid Synthesis Normal fatty acid synthesis primarily occurs in lipogenic tissues, especially adipose tissue ( de novo fatty acid synthesis to satisfy their needs for energy and intermediates under conditions of metabolic stress ( Fatty acid synthase (FASN) has been found to be overexpressed in TNBC tumor cells ( de novo fatty acids synthesis via transcriptional activation of corresponding lipogenic genes ( in vivo , and SREBP-1 overexpression can partially rescue this blockage ( Fatty Acid Oxidation Fatty acid oxidation (FAO) is a multi-step process that allows long-chain fatty acids to convert into fatty acid-CoA and enter the tricarboxylic acid (TCA) cycle and OXPHOS to be completely oxidized to sustain ATP production ( Fatty Acid Uptake and Storage In addition to de novo fatty acid synthesis, TNBC cells can also obtain fatty acids through absorbing dietary lipids from the blood circulation or by uptake of exogenous fatty acids derived from adipocytes in the microenvironment

10.1002/ana.21415 Ann