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7b) were equivalent after infection with wild-type or vCD44BP MCMV

In this regard, precision geromedicine should take into account that the expression of metabolizing enzymes (such as cytochrome P450 isoforms) and hepatic membrane transporters are regulated, like many other genes, by clock-dependent mechanisms, and influence intestinal absorption, hepatic uptake, and biliary and renal excretion of various drugs (Zhang et al., 2009

These include cancer, neurodegenerative disorders, cardiovascular and metabolic syndromes, inflammatory conditions, and fibrotic diseases

It is also characterized by iron overload and downregulated expression of anti-oxidant proteins, including glutathione peroxidases (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase 4 (GPX4)

doi: 10.21037/tau.2018.05.17 24 GiulioniCMauriziVDe StefanoVPolisiniGTeohJY-CMilaneseGet al