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doi: 10.1093/toxsci/53.2.340 149 ChenGYangYXuCGaoS

This is due to additional depletion of the NADPH pool, which is already significantly reduced when ADP-heptose biosynthesis is inhibited [7], since the accumulation of cystine in the cell should increase the consumption of reducing equivalents (NADPH) for the reduction of cystine to cysteine [22]