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In addition to CYP isoenzymes, kava extract also demonstrated an inhibitory reversible effect on monoamine oxidase (MAO)-A and MAO-B activities of mouse brain, leading to research interest in the potential anti-parkinsonian and antidepressant activity of kava [52,53]

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Acknowledgements This work was supported by grants from the National multidisciplinary collaborative diagnosis and treatment capacity building project for major diseases (TJZ202104), the Natural Science Foundation of China (82270643, 82070644, 82170621 and 82370645), the Science and Technology Major Program of Sichuan Province (2022ZDZX0019), the Sichuan Science and Technology Program (2024NSFSC0645), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18008, ZYGD22006)