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The competition for arginine use as a substrate also depletes the pool available for NOS2 use, inhibiting NO production and hence inflammation [113]

Animal Model:Male C57BL/6 mice (8-week-old) [4] Dosage:50 mg/kg Administration:Oral gavage

Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1)

Protocol Overview Duration: 28 days (1 vial) Application Schedule: Monday to Friday Daily application on weekdays only Weekend breaks are built into the protocol for balance and consistency Recommended Dose: Applied daily according to the established research protocol to ensure stable and controlled exposure over the 28-day cycle