L-serine (synthesized via PHGDH) is a key rate-limiting factor for maintaining steady-state levels of D-serine in the adult brain ( N -methyl-D-aspartate (NMDA) receptor function at least in the hippocampus ( Conclusion The treatment of a complex disease such as epilepsy warrants novel treatment approaches, even in an era of ample available ASM ( The KD is such a therapy modulating various distinct pathways as underlined by a plethora of pre-clinical data ( Bacteroidetes and proteobacteria in the gut ( Even though different mechanisms of the KD have been reviewed the last few years ( via PHGDH
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It is required for rapidly dividing cells, including those of the gut, and is a precursor of the brain neurotransmitter glutamate