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Bone Res 13 , 72 (2025)

Although phentermine is one of the most commonly prescribed weight-loss medications, it has some potentially serious drawbacks

Zinc: The Japanese semaglutide study that found B12 decline also documented significant zinc decreases

Anecdotal reports from research settings suggest mild stimulant-like effects in some individuals

A first step in overcoming these problems would be an assessment of anti-angiogenic drugs in clinical trials where patients are selected according to predictive biomarkers (e.g., the vascular pattern)