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5.4 Use in Women of Childbearing Potential Because of the risk to the fetus of decreased IQ and major congenital malformations (including neural tube defects), which may occur very early in pregnancy, valproate should not be administered to a woman of childbearing potential unless the drug is essential to the management of her medical condition

This was accompanied by an increased content of CD206+ cells, Ym1 markers, and a reduction of CD11c+ cells, along with IL-10 in the epididymal white adipose tissue extracted stromal vascular fractions