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Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 (Attia et al., 2023)

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Maintains muscle strength: It resolves and prevents muscle weakness [2]

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The regulation of neurotransmitter levels in the brain by electrical stimulation of the vagus nerve can be used to treat epilepsy and depression [124], Gut bacteria-related products such as LPS can also activate vagus nerve afferents at the myelin level of the vagus nerve, thereby affecting brain function [125]