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Mechanistic studies have revealed that the application of Gln metabolic inhibitors or the knockdown of the transmembrane protein SLC1A5 can inhibit the YAP1/TEAD signaling cascade, which is known to promote mesothelioma invasion and metastasis ( 2.1.2 Promoting drug resistance in tumor cells The dysregulation of Gln metabolism is closely associated with the development of tumor resistance (24)

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Alexandra M V, Daniel P, Kari Ann S, Darren J P, Marguerite S B, Vivek T-M et al

Liposomes are microscopic spheres built from the same fat-like material (phospholipids) as your own cell membranes

Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating pd-L1 expression on neutrophil in hepatocellular carcinoma