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Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death

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ABR peak-to-peak amplitudes were defined as the voltage difference, in microvolts, from the peak to the subsequent negative trough

These manifestations stem from mitochondrial dysfunction, often caused by mutations in genes related to mitochondrial function, leading to impaired energy production and widespread neurological and metabolic abnormalities