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Increasing the concentration of active metabolites at the tumor site, will subsequently limit the concentration of active drug at other sites, reducing side effects

Padler-KaravaniVYuHCaoHChokhawalaHKarpFVarkiNet alDiversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease

Although the majority of HFS are idiopathic, presumably due to irritation or compression of the facial nerve by an aberrant blood vessel in the middle or posterior fossa or other vascular condition (e.g., arteritis), there are other causes of facial nerve compression, including tumors [ 19 , 23 ]

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309 This reduction is achieved through partial inhibition of Complex I of the mitochondrial ETC