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In summary, despite the challenges posed by tumour heterogeneity, diverse microenvironmental adaptability, and safety concerns, targeted therapies aimed at ROS and related PCD pathways offer new perspectives for precision medicine in breast cancer

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In obese mice, 14 days of AOD-9604 treatment reduced body weight gain by over 50% compared to controls

Interestingly, inherited mitochondriopathies do not usually present with parkinsonian features [with some notable exceptions, such as in POLG mutation carriers (Ma et al., 2020)]