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Synthesis of (6S)-5-formyltetrahydropteroyl-polyglutamates and interconversion to other reduced pteroylpolyglutamate derivatives

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18 The treatment protocol for TPE consists of removing and retaining a considerable volume of plasma, approximately 1 to 1.5 plasma volume, 17 and returning the necessary cellular components via a colloid or combination colloid/crystallization solution of either fresh frozen plasma (FFP) or albumin

HIF-1 predominantly regulates glycolysis, OXPHOS, and mitochondrial biogenesis, while HIF-2 primarily regulates erythropoiesis, blood vessel remodeling, and cell cycle progression [33,34,35]