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The importance of considering circadian rhythm and metabolic regulation in drug design is emphasized

RSL3 is known to interact with thioredoxin reductase 1 (Txnrd1) which also plays a role in DNA damage and oxidative stress 31

Therefore, further elucidating the pathogenesis of RA and identifying new therapeutic targets will help develop more personalized, effective, and safe treatment approaches, thereby improving the quality of life of RA patients and reducing the socioeconomic burden of the disease