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Strategies of structure-based enzyme redesign and in vivo-directed evolution are adopted, until all the rate-limiting steps are solved and the conversion rate of end product reaches 95%

Parca, L., Beck, M., Bork, P

For example, after supplementation with Omega-3 PUFA, the abundance of Escherichia, Faecalibacterium and Veronella was detected in the IBD group, while the abundance of Bacteroides and Flavobacterium was decreased (117, 118)

(2019b), increased BDNF levels, greater populations of butyrate-producing bacteria, and modulation of the HPA-axis were noticed in mice administered the Bifidobacterium longum subspecies infantis strain CCFM687 and developing depressive-like behavior as a consequence of stress