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However, it remains unclear whether hepatic steatosis per se in MAFLD contributes to an elevated risk of mortality in individuals with overweight/obesity, metabolic dysregulation, or type 2 diabetes mellitus (DM) (referred to as the metabolic dysfunction-association (MA) group), which are known significant risk factors for increased mortality

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Excessive ROS can also reduce the Ca 2+ sensitivity of myofibril and damage the contractile function of muscle, possibly through enzyme complexes i and iii (Ci, Ciii)-dependent and/or reduced nicotinamide adenine dinucleotide (NADPH) oxidase-dependent pathways

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