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Optimization of the initial binding molecules led to the development and discovery of LSN3353871, which binds to K IV 8, K IV 78 and K IV 58 with K d values of 756 nM, 605 nM and 423 nM, respectively, as determined by isothermal calorimetry (ITC) (Fig

ERAD plays a protective role by clearing misfolded insulin and maintaining ER function, thereby supporting glucose-stimulated insulin secretion (GSIS)