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Diabetes 28 , 899904 (1979)

Series B, Containing Papers of a Biological Character

This 3 3 phase 1 clinical trial assessed curcumin (1200 mg/day) and ursolic acid (300 mg/day), both alone and in combination, over 2 weeks, revealing no grade 3 or 4 adverse events, along with very minimal alterations in safety laboratory results

Table 2 shows the identity of the four protein spots, the proteins were calretinin, F-actin, annexin A3 and beta-centractin

From the above findings, it was presumed that the anti-inflammatory action of the Si-based agent was mediated by two mechanisms: a direct anti-inflammatory action via the generated hydrogen and an indirect anti-inflammatory action through the induced RSS