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Peer review Peer review information Nature Communications thanks Christopher Toseland and Anniina Vihervaara for their contribution to the peer review of this work

The severity and frequency of these adverse events is dose-dependent, but both can be reduced with slower stepwise dose titration

The 2000s marked a mechanistic leap, as it was demonstrated that suppression of nocturnal melatonin through LAN enhanced BC cellular metabolism and growth in breast cancer xenografts, providing compelling evidence of a link between circadian biology and tumor progression 52,53,54