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Meanwhile, Kd of Sororin-PDS5B (cyan) was about 0.54 M (Fig

Anorectal manometry (often with balloon-expulsion testing) is the appropriate next diagnostic step to assess sphincter function and defecatory coordination and to guide therapy

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However, the capacity of sulfation is limited and competition between APAP and p -cresol will limit the detoxication of both by this route, increasing the likely formation of NAPQI as metabolism is pushed towards CYP2E1