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58 The upstream regulatory regions of the gene-encoding heme oxygenase 1 contain multiple AREs, which are responsible for its robust inducibility by various small-molecule Nrf2 activators

To address this, researchers developed an oral delivery system using supramolecular nanoparticles composed of tannic acid and a lipid-PEG that encapsulated infliximab, protecting the antibody from the gastrointestinal environment ( Figure 7B ) (153)

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