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It selectively hydrolyzes GSH, producing Cys-Gly and 5-oxoproline (a cyclized form of glutamate) (11,51), thereby accelerating formation of the cellular oxidative environment

Moreover, traditional drug delivery systems (DDSs)primarily oral tablets and intravenous injectionsfail to address localized MSU crystal deposition or provide sustained drug release, leading to recurrent flares and chronic joint damage (Mohamad et al., 2025

Adherence to treatment is also an important area that determines efficacy and likelihood of reducing ECOPD

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Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet