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It is known that the intrinsic pathway of apoptosis involves the mitochondria release of pro-apoptotic factors, such as AIF or cytochrome c, and these processes can be activated by ROS

Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes

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This approach not only led to natural acidification and stabilization of the extract but also likely preserved a broader spectrum of bioactive compounds that might be altered or lost in conventional methods