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Although this approach is widely used in experimental wound-healing studies, it does not allow definitive immunophenotypic characterization of inflammatory cell subtypes, macrophage polarization, or angiogenic markers

The differential proteins were analyzed by volcano plot and hierarchical cluster

Nevertheless, there is a lack of research about the benefits of SeNPs in clinical settings, although they constitute a good candidate for advanced-stage clinical research due to their low toxicity and excellent biocompatibility [61,67]

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In fact, a study involving 45 adults with chronic kidney disease found that taking 200 mg of selenium daily for three months led to a significant increase in their glutathione peroxidase levels