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Overcoming metabolic heterogeneity-driven resistance: multidimensional interventions and translational advances To overcome resistance driven by metabolic heterogeneity in CRC, current research is advancing multi-layered and pathway-diverse intervention strategies [125]

This synaptic plasticity process involves several activities that alter synaptic proteins, including glutamate receptors (-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate and N-methyl-D-aspartate (NMDA), postsynaptic density protein 95 (PSD-95), and other kinases such as calmodulin-dependent kinase II (CaMKII) and protein kinase C (PKC), to modify the synaptic structure (Alhowail and Aldubayan, 2023