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CrossRef Neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice Gatan Prvost, Arnaud Arabo, Marie-Anne Le Solliec, Justine Bons, Marie Picot, Julie Maucotel, Hind Berrahmoune, Mouna El Mehdi, Saloua Cherifi, Alexandre Benani, Emmanuelle Ndlec, Mose Coffier, Jrme Leprince, Anneli Nordqvist, Valry Brunel, Pierr American Journal of Physiology-Endocrinology and Metabolism.2019

Leenders, F

For a completely different side effect profile, consider bupropion-naltrexone (Contrave)

If GI symptoms are still significant at the end of a four-week block, the documented approach is to hold the current dose longer rather than escalate on schedule