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The alleged involvement of reactive oxygen species and antioxidants is the basis of the pathology of melasma

However, the tumoral environment select populations with different dependences on mitochondria metabolism due to metabolic adaptation and plasticity

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P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib