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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.de Jong MD, Simmons CP, Thanh TT, et al

Oxidative stress can be mediated by several different mechanisms but is frequently linked to inflammation

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FIGURE 8 Discussion The two oxidation states of copper, Cu + and Cu 2+ , allow its participation in essential redox reactions, but can also promote the formation of ROS that causes cellular damage (Vulpe and Packman, 1995