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But do a patch test first to avoid irritation problems

It can also occur during post-cleavage purification in TFA/H 2 O/ACN mixtures, or if lyophilized peptides are stored at mildly acidic pH (5-6)

Many newly developed DUB inhibitors, such as Novartis's CSN5i-3 (102) or the already marketed drug pimozide (103), have been found to exhibit significant functions in the field of cancer therapy