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The cell viability assay showed that curcumin analogue, MS13 (1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien e-3-one) has a greater cytotoxicity effect on SW480 (EC50: 7.52.8 M) and SW620 (EC50: 5.72.4 M), compared with curcumin (SW480, EC50: 30.61.4 M) and SW620, EC50: 26.82.1 M)