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doi: 10.1016/j.healun.2016.08.017 63 Tremblay-GravelMRacineNDucharmeAPelletierGBGiraldeauGLiszkowskiMet al

As we get older, mitochondria accrue more and more mutations, release more and more inflammation provoking debris (Munoz-Pinto et al., 2021), countermeasures to mitigate the harm begin to fail (Lane, 2015), and keeping the microbiota healthy becomes less and less feasible