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Despite B cells playing a key role in the SLE pathogenesis, B cell depletion with current monoclonal antibodies such as belimumab fails to achieve symptom remission in many lupus patients ( Initially, studies in murine models of SLE showed efficacy of anti-CD19 CAR-T therapy in B-cell depletion and reduction of disease progression ( Long-term follow-up of 8 SLE patients, including the previously mentioned patient, demonstrated significant progress with CD19 CAR-T therapy

Typical treatment protocols: Cycles of 5 days per week for 1-3 months, followed by 2-4 weeks off

To further elucidate the potential role of CD36 in PA-induced ferroptosis, we generated efficient stable-transfected cell lines overexpressing the CD36 protein from MCF-7 (MCF-7-CD36) and SUM-159 cells (SUM-159-CD36)

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This shift in perspective followed comprehensive single-cell transcriptomic studies, which revealed that astrocytes differ in function and gene expression, depending on the specific environmental stressors and pathological conditions (Liddelow et al., 2017