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10.1016/0024-3205(94)00796-9 74 SikiricP.SeiwerthS.RucmanR.DrmicD.StupnisekM.KokotA.et al (2017)

Relative contraindications (metformin use, proton pump inhibitors) require monitoring

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In contrast to the reversibly hyperoxidized cysteine sulfenylated proteins, irreversibly hyperoxidized sulfonylated cysteine is generally thought to be an impaired dead end product (e.g., inactivated protein) formed through protein aggregation 25

As for the thyroid hormone and its receptor, there appears to be no reported direct interaction with the POMC promoter, although POMC -/- animals are known to display primary hyperthyroidism (34)