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Karki et al., 2014) in their effort to prove that raloxifene (RX) upregulates glutamate transporters in rat primary astrocytes, found that this happens through the activation of multiple signaling pathways including ERK, EGFR, and CREB mediated by estrogen receptors (ERs) ER-a, ER-b, and GPR30

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It also found that expression of Nrf2 was much higher in the livers of mice which fed with a high-fat diet than those fed with normal chow (Sano et al., 2021)