observed that aging is associated with lower antioxidant defense capacity (catalase activity and GSH levels), higher levels of oxidative compounds (XO activity/expression, superoxide, ROS, and GSSG levels), and increased lipofuscin accumulation, along with impaired immune cell functions such as macrophages 116
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Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants
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