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Researchers have examined its interaction with pathways associated with nitric oxide signaling, endothelial function, and extracellular matrix repair

In a first-in-human clinical trial (NCT02491281), LNA043 was administered via intra-articular injection before total knee replacement, and results showed that LNA043 could reverse the transcriptome signature associated with osteoarthritis by promoting the expression of hyaline cartilage matrix components and anabolic signaling pathways [435]

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Br J Diabetes Vasc Dis 4(6):401406 Singh A et al (2013) Association of B12 deficiency and clinical neuropathy with metformin use in type 2 diabetes patients

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