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This showed ( S )-dHTC1 occupying the IMiD-binding site of CRBN, positioning its spirosuccinimide moiety within the tritryptophan cage formed by W380, W386 and W400 (Extended Data Fig

doi: 10.1161/01.CIR.0000112605.43318.CA 64 JrvelS.BraggeH.PaunuN.JrvelT.PaljrviL.KalimoH.et al

Whether combining ferroptosis-related HNC treatments with existing HNC treatments may produce improved outcomes, as well as how the adverse effects of ferroptosis in the treatment of HNC can be avoided, are questions to be addressed by future research