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The extracts efficiency is attributed to terpenoids, organic acids, and flavonoids

GLUTATHIONE-INVOLVING HEAVY METAL DETOXIFICATION AND TOLERANCE IN PLANTS Glutathione (GSH) is an excellent source of thiol in cells that are located in several cellular organelles such as vacuole (VC), mitochondria (Mt), chloroplast (ChP), and endoplasmic reticulum (EPR)

To test this hypothesis, we used several ovarian cancer cell lines, including serous carcinoma (OSC - OVCAR3 and OVCAR8), sensitive and resistant to Cisplatin A2780 (A2780 parental and A2780 cisR) unspecified histotype ovarian carcinoma cells and clear cell carcinoma (OCCC-ES2) cells

Further analysis of EcGGT in complex with substrate analogs, acivicin and azaserine, revealed that they formed a tetrahedral adduct (structurally analogous to transient acyl-enzyme intermediate) with the enzyme (Wada et al., 2008)

Mller A, Gabriel H, Sies H (1985) A novel biologically active selenoorganic compoundIV: protective glutathione-dependent effect of PZ 51 (Ebselen) against ADP-Fe induced lipid peroxidation in isolated hepatocytes