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4.3 Mitophagy and metabolic-associated fatty liver diseases Metabolic associated fatty liver disease (MAFLD) refers to a series of diseases caused by multi-systemic metabolic dysfunction resulting in chronic liver damage, including hepatic steatosis, NAFLD, hepatic fibrosis, liver cirrhosis, hepatocellular carcinoma, and others ( In vitro , CP upregulates the protein levels of PGC-1, PPAR, PINK1, Parkin, ATG7, and LC3I/II in free FA (FFA)-induced NAFLD cell models, activates the PINK1-Parkin signaling pathway to promote mitophagy in liver cells, and inhibits FFA-induced OS and lipid accumulation

Scientific literature Schmidbauer C, Hofsttter G

Newborn calves are an important component of livestock production worldwide, whether for breeding or meat production 2

CDDP and methotrexate (MTX) can induce acute kidney injury through direct toxicity to renal tubular epithelial cells, apoptosis activation, oxidative stress, mitochondrial damage, or drug crystallization within renal tubules [67,68,69]

Statistical software SPSS version 17.0 (SPSS inc., 233 South Wacker Drive, 11th floor, Chicago, IL, USA) trial was used for analysis