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The catalytic activity is only initiated when an association is established, in balance status, between the dimeric and tetrameric 6 forms

IV is preferred due to variable oral bioavailability (discussed further below)

Among the malignancies found in the genitourinary (GU) system, renal cell carcinoma (RCC) and urothelial carcinoma (UC) benefit most from immune-checkpoint inhibitors (ICIs) alone or in combination with other ICIs or tyrosine kinase inhibitors (TKIs)