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The transcription of IL-12 in the BacA group was upregulated at 12- and 14-weeks post-inoculation and it was significantly higher than wild-type and IcL groups at 12- and 14-weeks post inoculation, respectively ( Figures 7A, B )

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125,246 This one-carbon metabolic remodeling undermines NADPH production, which sensitizes affected cells to oxidative stress and may facilitate inflammation and cell death